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In addition, simvastatin dosing should not exceed 20 mg once daily owing to increased exposure

Some of the B12 from the liver is excreted in the bile and reabsorbed in the intestines through a process known as enterohepatic circulation (Shibboleth Authentication Request, n.d.)

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In 1973, Loren Pickart and Margaret Thaler reported that a small factor in human serum could prolong the survival of normal liver cells and modulate growth in liver tissue, and that plasma from younger donors was more active than plasma from older donors

Administration: Intravenous infusion, 10-30mL diluted in saline given over 15-60 minutes